TY  - JOUR
PY  - 2004//
TI  - Hydroxycarbazepine distribution in three postmortem cases
JO  - Journal of analytical toxicology
A1  - Levine, Barry
A1  - Green-Johnson, Deborah
A1  - Moore, Karla A.
A1  - Fowler, David R.
SP  - 509
EP  - 511
VL  - 28
IS  - 6
N2  - This paper presents three cases investigated by the Office of the Chief Medical Examiner where hydroxycarbazepine, the active metabolite of the anticonvulsant prodrug oxcarbazepine, was detected in the biological specimens submitted for toxicological analysis. Hydroxycarbazepine was quantitated using a single-step pH 5 extraction and detection on a DB-5 column by gas chromatography-nitrogen-phosphorus detection. In the three cases, the heart blood concentrations were 34.6, 40.5, and 3.7 mg/L, respectively. In cases 2 and 3, the peripheral blood concentrations were 36 and 4.1 mg/L, respectively. In each case, the medical examiner ruled that the hydroxycarbazepine was an incidental finding to the cause of death.<p /> <p>Language: en</p>
LA  - en
SN  - 0146-4760
UR  - http://dx.doi.org/10.1093/jat/28.6.509
ID  - ref1
ER  -