TY  - JOUR
PY  - 2003//
TI  - Analysis of metformin in antemortem serum and postmortem specimens by a novel HPLC method and application to an intoxication case
JO  - Journal of analytical toxicology
A1  - Moore, Karla A.
A1  - Levine, Barry
A1  - Titus, Jack M.
A1  - Fowler, David R.
SP  - 592
EP  - 594
VL  - 27
IS  - 8
N2  - A case of intoxication from the oral hypoglycemic drug metformin is presented. A number of published liquid chromatographic methods were combined to enable a simplified analysis of metformin in both antemortem and postmortem specimens. The method involved direct injection of a protein-free filtrate into the liquid chromatograph. The method was sufficiently sensitive to detect therapeutic use of metformin; no common therapeutic or abused drugs interfered with the assay. In the presented case, the hospital admission serum metformin concentration was 141 mg/L, or approximately two orders of magnitude above therapeutic concentrations. The medical examiner concluded that the cause of death in this case was metformin intoxication, and the manner of death was suicide.<p /> <p>Language: en</p>
LA  - en
SN  - 0146-4760
UR  - http://dx.doi.org/10.1093/jat/27.8.592
ID  - ref1
ER  -