TY  - JOUR
PY  - 2002//
TI  - [High-dose fluoxetine-induced mania. Review and case report]
JO  - Vertex: Revista Argentina de Psiquiatria
A1  - Ruiz, Martín
A1  - Vairo, Carolina
A1  - Matusevich, Daniel
A1  - Finkelsztein, Carlos
SP  - 93
EP  - 97
VL  - 13
IS  - 48
N2  - We report the case of a 53 year old woman who attempted suicide taking one high-dose of fluoxetine, developing a manic episode 19 days later. We also make a review about antidepressant-induced mania. In patients with mood disorder, the frequency of antidepressant-induced mania switch has been estimated to be 3.7 to 33%, varying across studies that included different diagnoses and different antidepressant treatments. Among the used data basis (Medline) there are papers reporting fluoxetine-induced mania. All of them include patients receiving adequate dose and time fluoxetine treatment. We found no reports of switch occurring after one high-dose of fluoxetine. As the impact on the clinical management of antidepressant-induced manic switches is quite high, several studies have focused on the possible clinical predictors of this phenomenon. By the time, is not possible to determine whether a manic episode is due to the natural course of bipolar disorder or to the medication. Thus, the phenomenon of antidepressant-induced mania should be defined and investigated with controlled prospective studies.<p /> <p>Language: es</p>
LA  - es
SN  - 0327-6139
UR  - http://dx.doi.org/
ID  - ref1
ER  -