TY  - JOUR
PY  - 2000//
TI  - Neuroprotective aspects of a novel MAO-B inhibitor PF9601N
JO  - Neurobiology (Budapest, Hungary)
A1  - Perez, V.
A1  - Morón, J.
A1  - Pastó, M.
A1  - Unzeta, M.
SP  - 231
EP  - 236
VL  - 8
IS  - 3-4
N2  - PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than l-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57Bl/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.<p /> <p>Language: en</p>
LA  - en
SN  - 1216-8068
UR  - http://dx.doi.org/
ID  - ref1
ER  -