TY  - JOUR
PY  - 1991//
TI  - Synthesis of serine analogues to be used as modified phospho acceptor sites in substrates of protein kinase C
JO  - Recueil des Travaux Chimiques des Pays‐Bas
A1  - Broxterman, H.J.G.
A1  - Liskamp, R.M.J.
SP  - 46
EP  - 52
VL  - 110
IS  - 2
N2  - Serine and threonine analogues (compounds 2‐6) are readily accessible by reaction of the anion of N,N‐dibenzylglycine ethyl ester (1) with an appropriate carbonyl compound. These analogues will be incorporated into Protein Kinase C (PKC) substrates. The serine aldehyde derivative 7 was used for the preparation of the corresponding diethyl acetal 9. This compound was the starting material in the synthesis of the suicide precursor 8, featuring a reductive amination leading to 12 and a Lewis‐acid‐catalysed cyclization giving 8. Copyright © 1991 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim<p /> <p>Language: en</p>
LA  - en
SN  - 0165-0513
UR  - http://dx.doi.org/10.1002/recl.19911100204
ID  - ref1
ER  -