TY  - JOUR
PY  - 1995//
TI  - The effects of bifemelane hydrochloride on depressive illness of the elderly
JO  - International journal of clinical pharmacology research
A1  - Yamagami, S.
A1  - Koide, S.
A1  - Mui, K.
A1  - Perk, S.
A1  - Hirayama, E.
A1  - Kioka, T.
A1  - Soejima, K.
A1  - Inoue, K.
A1  - Nishiwaki, S.
SP  - 1
EP  - 7
VL  - 15
IS  - 1
N2  - The therapeutic efficacy, utility and safety of bifemelane hydrochloride were studied in 52 elderly depressive patients. The drug was administered as a tablet containing 50 mg orally three times daily for 8 consecutive weeks. The final global improvement rating and global utility rating were respectively 80.8 and 73.1 percent for all patients. The improvement rates on the Hamilton depression rating scale (HAM-D) were more than 60% for depressed mood, guilt, suicide, middle insomnia, delayed insomnia, psychotic anxiety, gastro-intestinal symptom, hypochondriasis, depersonalization and derealization. The rates regarding global symptoms evaluated by the Psychoneurotic rating scale for doctor's use were more than 60% for tension, agitation, irritability and excitement, phobia, depression, hypochondria and nocturnal delirium in psychotic symptoms, and insomnia in addition to palpitation in somatic symptoms. A significant decrease was also observed in the symptoms covered by the Self-rating depression scale of Zung after treatment with this drug. There were no instances of side-effects, nor any abnormalities in laboratory tests, encountered throughout the trial. Therefore, bifemelane hydrochloride is of value for the treatment of geriatric depression.<p /> <p>Language: en</p>
LA  - en
SN  - 0251-1649
UR  - http://dx.doi.org/
ID  - ref1
ER  -