TY  - JOUR
PY  - 1994//
TI  - A fatal case of trazodone and dothiepin poisoning: toxicological findings
JO  - Journal of analytical toxicology
A1  - Lambert, W.
A1  - Van Bocxlaer, J.
A1  - Piette, M.
A1  - De Leenheer, A.
SP  - 176
EP  - 179
VL  - 18
IS  - 3
N2  - A fatal case of trazodone and dothiepin self-poisoning is presented. A multi-technique approach (EMIT, TLC, HPLC/DAD, and GC/MS) allowed the unequivocal identification of trazodone and dothiepin as toxicologically relevant substances. Both compounds were quantitatively determined in a number of postmortem samples. Blood and urinary trazodone concentrations (28.7 and 90.5 micrograms/mL, respectively) and dothiepin concentrations (2.1 and 9.7 micrograms/mL, respectively) were far above therapeutic concentrations (i.e., 1.5 and 0.05 microgram/mL for trazodone and dothiepin, respectively, in blood) and were clearly the cause of death in this particular case. These data confirm the high toxicity and the high mortality rate in trazodone intoxications, especially when co-ingestion of other substances is involved.<p /> <p>Language: en</p>
LA  - en
SN  - 0146-4760
UR  - http://dx.doi.org/10.1093/jat/18.3.176
ID  - ref1
ER  -