TY  - JOUR
PY  - 1992//
TI  - Efficacy of various water-soluble chelator molecules in the liposome-mediated macrophage "suicide" technique
JO  - Journal of pharmacological and toxicological methods
A1  - van Rooijen, N.
A1  - Poppema, A.
SP  - 217
EP  - 221
VL  - 28
IS  - 4
N2  - In earlier studies, we described a technique for the "in vivo" depletion of macrophages, using liposome-encapsulated dichloromethylene bisphosphonate (C12MBP). The aim of the present study was to compare the effects on macrophages of various other liposome-delivered Ca2+ chelators: EDTA, DTPA, and EGTA. It appeared that both EDTA and DTPA as well as Ca(2+)-and Cu(2+)-EDTA complexes were also effective in the elimination of splenic macrophages when encapsulated in liposomes and intravenously injected. EGTA, a well-known and frequently used Ca2+ chelator, had no effect.<p /> <p>Language: en</p>
LA  - en
SN  - 1056-8719
UR  - http://dx.doi.org/10.1016/1056-8719(92)90007-n
ID  - ref1
ER  -