TY  - JOUR
PY  - 1992//
TI  - Androst-5-ene-7,17-dione: a novel class of suicide substrate of aromatase
JO  - Biochemical and biophysical research communications
A1  - Numazawa, M.
A1  - Mutsumi, A.
A1  - Hoshi, K.
A1  - Tanaka, Y.
SP  - 32
EP  - 39
VL  - 186
IS  - 1
N2  - 5-En-7-one steroid 1 was found to be a potent inhibitor of aromatase. This along with its 19-hydroxy derivative 7 was characterized as suicide substrate of human placental aromatase (k(inact)'s of 0.069 and 0.058 min-1 and KI's of 143 nM and 11.1 microM, respectively, for steroids 1 and 7). The results suggest that the 19-oxygenation would be involved in the irreversible inactivation of aromatase by the 5-en-7-one steroids.<p /> <p>Language: en</p>
LA  - en
SN  - 0006-291X
UR  - http://dx.doi.org/10.1016/s0006-291x(05)80771-5
ID  - ref1
ER  -