TY  - JOUR
PY  - 1996//
TI  - Brain neuropeptidergic function in suicide victims
JO  - Human psychopharmacology
A1  - Arranz, B.
A1  - Blennow, K.
A1  - Ekman, R.
A1  - Eriksson, A.
A1  - Marcusson, J.
SP  - 451
EP  - 461
VL  - 11
IS  - 6
N2  - To examine how neuropeptide dysfunction may account for some of the behavioural and physiological alterations observed in depressive illness, neuropeptide Y (NPY), somatostatin (SOM) and corticotropin-releasing factor (CRF)-like immunoreactivity (LI), was measured in frontal cortex, gyrus cinguli and hypothalamus from 18 suicide victims and 23 matched controls. A high performance liquid chromatography separation of the NPY immunoreactive fragments was also performed. Overall suicides did not show significant differences with respect to the control group. However, a significant increase in NPY-LI was noted in the frontal cortex of those suicides dying from carbon monoxide poisoning. The chromatographic characterization showed a distinctly different NPY-LI peak pattern in the depressed suicides, which suggests the possibility of depression being associated with an alteration in the catabolic products of certain neuropeptidergic systems.<p /> <p>Language: en</p>
LA  - en
SN  - 0885-6222
UR  - http://dx.doi.org/10.1002/(sici)1099-1077(199611)11:6<451::aid-hup812>3.0.co;2-%23
ID  - ref1
ER  -