TY  - JOUR
PY  - 1993//
TI  - Synthesis and biological properties of selected nucleoside analogues
JO  - Recueil des Travaux Chimiques des Pays‐Bas
A1  - Koomen, G.J.
SP  - 51
EP  - 65
VL  - 112
IS  - 2
N2  - This paper reviews the research carried out in our laboratory in the field of nucleoside analogues, divided into two main parts: (1) Analogues with modified sugars, describing synthesis of monomers for polynucleotides, in which the ribose moiety has been replaced by amino acids, N‐vinyl‐2‐pyrolidinone, dihydroxy acyclic systems, tetrahydrofuran and tetrahydropyran rings, butyrolactone, pyrrolidine and cyclopentane/cyclopentane systems. (2) Analogues with modified bases, consisting of carbene adducts of pyrimidine nucleosides, benzodiazepine nucleosides, 5‐fluoro‐6‐vinyluracil, glutarimide nucleosides, transition state and suicide inhibitors of adenylosuccinate lyase and fluorescent pyrido[2,1‐i] purine nucleosides. Cytostatic and antiviral activities of a variety of the compounds obtained are discussed. Copyright © 1993 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim<p /> <p>Language: en</p>
LA  - en
SN  - 0165-0513
UR  - http://dx.doi.org/10.1002/recl.19931120202
ID  - ref1
ER  -