TY  - JOUR
PY  - 1992//
TI  - Synthesis of high specific activity tritium labeled (E)‐6‐(bromomethylene)‐tetrahydro‐3‐(1‐naphthalenyl)‐2H‐pyran‐2‐one as a selective probe for calcium‐independent phospholipase a2
JO  - Journal of Labelled Compounds and Radiopharmaceuticals
A1  - Durley, R.C.
A1  - Parnas, B.L.
A1  - Weiss, R.H.
SP  - 685
EP  - 691
VL  - 31
IS  - 9
N2  - The synthesis of (E)‐6‐(bromomethylene)‐tetrahydro‐3‐([4‐3H]‐1‐naphthalenyl)‐2H‐pyran‐2‐one at a specific activity of 24.0 Ci/mmol is described. This probe was synthesized to determine whether (E)‐6‐(bromomethylene)‐tetrahydro‐3‐(1‐naphthalenyl)‐2H‐pyran‐2‐one inhibits calcium‐independent myocardial phospholipase A2 irreversibly via covalent modification. The material was synthesized in four steps from 1‐naphthalene acetic acid via [4‐3H]‐1‐naphthaleneacetic acid. The yield from [4‐3H]‐1‐naphthaleneacetic acid was 29.7%. The radiochemical purity of the HPLC‐purified final product was 99.5%. Copyright © 1992 John Wiley & Sons, Ltd.<p /> <p>Language: en</p>
LA  - en
SN  - 0362-4803
UR  - http://dx.doi.org/10.1002/jlcr.2580310907
ID  - ref1
ER  -