TY  - JOUR
PY  - 2021//
TI  - Clinical features of the patients with major depressive disorder co-occurring insomnia and hypersomnia symptoms: a report of NSSD study
JO  - Sleep Medicine
A1  - Zhao, Jie
A1  - Liu, Hongmei
A1  - Wu, Zhiguo
A1  - Wang, Yun
A1  - Cao, Tongdan
A1  - Lyu, Dongbin
A1  - Huang, Qinte
A1  - Wu, Zhenling
A1  - Zhu, Yuncheng
A1  - Wu, Xiaohui
A1  - Chen, Jun
A1  - Wang, Yong
A1  - Su, Yousong
A1  - Zhang, Chen
A1  - Peng, Daihui
A1  - Li, Zezhi
A1  - Rong, Han
A1  - Liu, Tiebang
A1  - Xia, Yong
A1  - Hong, Wu
A1  - Fang, Yiru
SP  - 375
EP  - 381
VL  - 81
IS  - 
N2  - BACKGROUND: The co-occurrence of insomnia and hypersomnia symptoms in patients with major depressive disorder (MDD) is associated with suicidal ideation and functional impairment. The relationship between sleep disturbances and clinical features and outcomes may not be adequately studied. In this study, we measured the functional impairments and clinical features of co-occurring insomnia and hypersomnia symptoms in Chinese patients with MDD.  METHODS: A post-hoc analysis was performed on data from the National Survey on Symptomatology of Depression (NSSD), which assessed the MDD patients in 32 hospitals by a clinician-rating questionnaire. The clinical features and outcomes were compared among the following four groups: insomnia symptom only, hypersomnia symptom only, both insomnia and hypersomnia symptoms, no sleep disturbance, respectively.  RESULTS: Totally, 234 (7.15%) of 3275 participants with MDD co-occurred insomnia and hypersomnia symptoms. They had more depressive symptoms (27.41 ± 9.123), higher rate of suicide ideation (39.7%), more severe impairment in physical (58.1%), economic (32.9%), work (55.1%), and relationship with families (29.5%). Patients with both sleep disturbances were more likely to excessive worry about sleep, have suicidal ideation, the distress of social disharmony, more somatic symptoms, lack of energy, hyperphagia, loss of mood reactivity, and diurnal change, whereas less likely to have anxious mood.  LIMITATIONS: Sleep disorders were not diagnosed by current standard diagnostic criteria.  CONCLUSIONS: Patients co-occurring with both sleep disturbances are associated with a higher rate of suicide risk and poorer social function. Our study could provide implications for suicidal risk evaluation and the development of therapeutic strategies for depression.<p /> <p>Language: en</p>
LA  - en
SN  - 1389-9457
UR  - http://dx.doi.org/10.1016/j.sleep.2021.03.005
ID  - ref1
ER  -