TY  - JOUR
PY  - 2022//
TI  - Two cases of fatal methemoglobinemia caused by self-poisoning with sodium nitrite: A case report
JO  - Medicine (Baltimore)
A1  - Mun, Sung Hoon
A1  - Park, Gwan Jin
A1  - Lee, Ji Han
A1  - Kim, Young Min
A1  - Chai, Hyun Seok
A1  - Kim, Sang Chul
SP  - e28810
EP  - e28810
VL  - 101
IS  - 7
N2  - RATIONALE: Sodium nitrite intoxication reportedly causes severe methemoglobinemia. Recent studies reported that most clinically significant cases resulted from intentional exposure in suicidal attempts. We describe 2 cases of severe methemoglobinemia secondary to intentional sodium nitrite intoxication in suicidal attempts.  PATIENTS CONCERNS: A 26-year-old man and 20-year-old woman attempted suicide by taking sodium nitrite, and were brought to the emergency department.  DIAGNOSIS: The male patient collapsed at the scene. He ingested approximately 18 g of sodium nitrate, and his methemoglobin level was 90.3%. The female patient was conscious, but was cyanotic. She ingested approximately 12.5 g of sodium nitrite, and her methemoglobin level was 54.6%.  INTERVENTIONS: The male patient received advanced cardiac life support in the emergency department. Methylene blue was immediately administered for the female patient.  OUTCOMES: The male patient died despite aggressive resuscitation. The female patient's cyanosis resolved, and her methemoglobin level decreased to 1.2% 3 hours later.  LESSONS: The immediate administration of methylene blue in severe methemoglobinemia patients prevented fatal consequences. The public should be informed about the accessibility and toxicity of sodium nitrite.<p /> <p>Language: en</p>
LA  - en
SN  - 0025-7974
UR  - http://dx.doi.org/10.1097/MD.0000000000028810
ID  - ref1
ER  -