TY  - JOUR
PY  - 2022//
TI  - Prevalence of psychotic symptoms and their impact on course and outcome of patients with bipolar disorder: Findings from the Bipolar Disorder Course and Outcome study from India (BiD-CoIN study)
JO  - Journal of affective disorders
A1  - Grover, Sandeep
A1  - Avasthi, Ajit
A1  - Chakravarty, Rahul
A1  - Dan, Amitava
A1  - Chakraborty, Kaustav
A1  - Neogi, Rajarshi
A1  - Desouza, Avinash
A1  - Nayak, Omkar
A1  - Kumar Praharaj, Samir
A1  - Menon, Vikas
A1  - Ramandeep, null
A1  - Bathla, Manish
A1  - Subramanyam, Alka A.
A1  - Nebhinani, Naresh
A1  - Ghosh, Prasonjit
A1  - Lakdawala, Bhavesh
A1  - Bhattacharya, Ranjan
SP  - 233
EP  - 239
VL  - 305
IS  - 
N2  - AIM: Most of the available data on the prevalence and impact of psychotic symptoms on the course of bipolar disorder (BD) is from Western countries. We aimed to study the prevalence of at least one psychotic episode in the lifetime in patients with BD and its association with the long-term course and outcome.  METHODOLOGY: 773 patients recruited as part of the Bipolar Disorder Course and Outcome study from India (BiD-CoIN study) were divided into 2 groups, based on the presence or absence of at least one psychotic episode in the lifetime.  RESULTS: 326 (42.2%) patients had at least one psychotic episode in their lifetime. At least one psychotic episode in the lifetime was associated with overall more severe illness in terms of lower age of onset, a higher number of episodes in the first 5 years of illness; higher rates of BD-II, a higher rate of lifetime history of at least 1 suicide attempt, lifetime history of hospitalization, history of receiving Electroconvulsive Therapy, and a higher prescription rates of antipsychotics. However, presence of psychotics symptoms was associated with better cognitive functioning.  CONCLUSIONS: Our findings suggest that the presence of psychotic symptoms during episodes in patients with BD is associated with poorer course of BD.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2022.02.070
ID  - ref1
ER  -