TY  - JOUR
PY  - 2021//
TI  - Increasing Prevalence of Anxiety and Depression Disorders After Diagnosis of Chronic Pancreatitis: A 5-Year Population-Based Study
JO  - Pancreas
A1  - Alkhayyat, Motasem
A1  - Abou Saleh, Mohannad
A1  - Coronado, Wendy
A1  - Abureesh, Mohammad
A1  - Al-Otoom, Omaymah
A1  - Qapaja, Thabet
A1  - Mansoor, Emad
A1  - Simons-Linares, C. Roberto
A1  - Stevens, Tyler
A1  - Chahal, Prabhleen
SP  - 153
EP  - 159
VL  - 50
IS  - 2
N2  - OBJECTIVES: Chronic pancreatitis (CP) is often associated with poor quality of life. Only a few small associative studies have reported the prevalence of mood disorders in CP. Using a large database, we sought to describe the epidemiology and risk association of anxiety and depression in CP and evaluate their outcomes.  METHODS: A multicenter database (Explorys), an aggregate of electronic health record data from 26 US healthcare systems, was surveyed. A cohort of patients with a diagnosis of CP between 2014 and 2019 was identified. Within this cohort, rates of anxiety and depression were calculated. Demographics, comorbidities, and outcomes were described.  RESULTS: Of the 30,276,810 individuals in the database (2014-2019), 67,260 patients had a CP diagnosis (0.22%). When compared with patients with no history of CP, patients with CP were more likely to develop anxiety (odds ratio, 6.94; 95% confidence interval, 6.85-7.04) and depression (odds ratio, 5.09; 95% confidence interval, 5.01-5.17). Chronic pancreatitis patients with depression had an increased risk of suicidal ideation compared with controls.  CONCLUSIONS: Patients with CP are at a higher risk of developing anxiety and depression compared with those without CP, with overall worse outcomes. Clinicians should screen CP patients and make appropriate referral to psychiatry when indicated.<p /> <p>Language: en</p>
LA  - en
SN  - 0885-3177
UR  - http://dx.doi.org/10.1097/MPA.0000000000001746
ID  - ref1
ER  -