TY  - JOUR
PY  - 2022//
TI  - Determinants of three-year clinical outcomes in real-world outpatients with bipolar disorder: The multicenter treatment survey for bipolar disorder in psychiatric outpatient clinics (MUSUBI)
JO  - Journal of psychiatric research
A1  - Katsumoto, Eiichi
A1  - Edagawa, Koji
A1  - Goto, Eiichiro
A1  - Hongo, Seiji
A1  - Shimoda, Kazutaka
A1  - Watanabe, Koichiro
A1  - Tsuboi, Takashi
A1  - Kikuchi, Toshiaki
A1  - Nakagawa, Atsuo
A1  - Yoshimura, Reiji
A1  - Kato, Masaki
A1  - Ueda, Hitoshi
A1  - Yasui-Furukori, Norio
A1  - Azekawa, Takaharu
A1  - Miki, Kazuhira
A1  - Watanabe, Yoichiro
A1  - Kubota, Yukihisa
A1  - Adachi, Naoto
A1  - Sugawara, Norio
SP  - 683
EP  - 692
VL  - 151
IS  - 
N2  - BACKGROUND: There is limited evidence regarding predictors of long-term clinical outcomes in patients with bipolar disorder (BD). The objective of this study was to describe 3-year clinical outcomes and identify their predictors from participants in the multicenter treatment survey for BD in psychiatric outpatient clinics (MUSUBI). <br><br>METHODS: The MUSUBI was a naturalistic study investigating patients with BD in real-world clinical practice. Our study extracted data regarding 1647 outpatients with BD from 2016, 2017, and 2019 as baseline, 1-year, and 3-year assessments. As clinical outcomes, we assessed the presence of time ill (depressive and manic) during the 1 year prior to the 3-year assessment and durable remission (53 weeks or more) prior to the 3-year assessment. <br><br>RESULTS: Participants with durable remission prior to the 3-year assessment had significant associations with diagnosis of a personality disorder and duration of continuous remission at baseline. Regarding the presence of depressive symptoms during the 1 year prior to the 3-year assessment, work status, Global Assessment of Functioning (GAF) scores, suicidal ideation, and duration of continuous remission at baseline had significant associations with this outcome. <br><br>CONCLUSIONS: At the 3-year assessment, 19.3% of participants (318/1647) achieved durable remission, while 47.5% of them (782/1647) were not remitted. Our findings can help clinicians predict the illness course of BD by understanding demographic and clinical characteristics.<p /> <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2022.05.028
ID  - ref1
ER  -