TY  - JOUR
PY  - 2022//
TI  - Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
JO  - Molecular psychiatry
A1  - van Velzen, Laura S.
A1  - Dauvermann, Maria R.
A1  - Colic, Lejla
A1  - Villa, Luca M.
A1  - Savage, Hannah S.
A1  - Toenders, Yara J.
A1  - Zhu, Alyssa H.
A1  - Bright, Joanna K.
A1  - Campos, Adrian I.
A1  - Salminen, Lauren E.
A1  - Ambrogi, Sonia
A1  - Ayesa-Arriola, Rosa
A1  - Banaj, Nerisa
A1  - Başgöze, Zeynep
A1  - Bauer, Jochen
A1  - Blair, Karina
A1  - Blair, Robert James
A1  - Brosch, Katharina
A1  - Cheng, Yuqi
A1  - Colle, Romain
A1  - Connolly, Colm G.
A1  - Corruble, Emmanuelle
A1  - Couvy-Duchesne, Baptiste
A1  - Crespo-Facorro, Benedicto
A1  - Cullen, Kathryn R.
A1  - Dannlowski, Udo
A1  - Davey, Christopher G.
A1  - Dohm, Katharina
A1  - Fullerton, Janice M.
A1  - Gonul, Ali Saffet
A1  - Gotlib, Ian H.
A1  - Grotegerd, Dominik
A1  - Hahn, Tim
A1  - Harrison, Ben J.
A1  - He, Mengxin
A1  - Hickie, Ian B.
A1  - Ho, Tiffany C.
A1  - Iorfino, Frank
A1  - Jansen, Andreas
A1  - Jollant, Fabrice
A1  - Kircher, Tilo
A1  - Klimes-Dougan, Bonnie
A1  - Klug, Melissa
A1  - Leehr, Elisabeth J.
A1  - Lippard, Elizabeth T. C.
A1  - McLaughlin, Katie A.
A1  - Meinert, Susanne
A1  - Miller, Adam Bryant
A1  - Mitchell, Philip B.
A1  - Mwangi, Benson
A1  - Nenadic, Igor
A1  - Ojha, Amar
A1  - Overs, Bronwyn J.
A1  - Pfarr, Julia-Katharina
A1  - Piras, Fabrizio
A1  - Ringwald, Kai G.
A1  - Roberts, Gloria
A1  - Romer, Georg
A1  - Sanches, Marsal
A1  - Sheridan, Margaret A.
A1  - Soares, Jair C.
A1  - Spalletta, Gianfranco
A1  - Stein, Frederike
A1  - Teresi, Giana I.
A1  - Tordesillas-Gutierrez, Diana
A1  - Uyar-Demir, Aslihan
A1  - van der Wee, Nic J. A.
A1  - van der Werff, Steven J.
A1  - Vermeiren, Robert R. J. M.
A1  - Winter, Alexandra
A1  - Wu, Mon-Ju
A1  - Yang, Tony T.
A1  - Thompson, Paul M.
A1  - Renteria, Miguel E.
A1  - Jahanshad, Neda
A1  - Blumberg, Hilary P.
A1  - van Harmelen, Anne-Laura
A1  - Schmaal, Lianne
SP  - 4550
EP  - 4560
VL  - 27
IS  - 11
N2  - Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation (N = 223). In separate analyses, MRI metrics were compared among HCs (N = 253), CCs (N = 217), and suicide attempters (N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (N = 163) than those without a lifetime suicide attempt (N = 323; FDR-p = 0.035, Cohen's d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.<p /> <p>Language: en</p>
LA  - en
SN  - 1359-4184
UR  - http://dx.doi.org/10.1038/s41380-022-01734-0
ID  - ref1
ER  -