TY  - JOUR
PY  - 2022//
TI  - Variability and concordance among indices of brain activity in major depressive disorder with suicidal ideation: A temporal dynamics resting-state fMRI analysis
JO  - Journal of affective disorders
A1  - Li, Weicheng
A1  - Wang, Chengyu
A1  - Lan, Xiaofeng
A1  - Fu, Ling
A1  - Zhang, Fan
A1  - Ye, Yanxiang
A1  - Liu, Haiyan
A1  - Wu, Kai
A1  - Zhou, Yanling
A1  - Ning, Yuping
SP  - 70
EP  - 78
VL  - 319
IS  - 
N2  - OBJECTIVE: The resting-state functional magnetic resonance imaging (rs-fMRI) have been used to explore functional abnormality of the brain in MDD patients with suicidal ideation (SI). However, few studies reported the variability and concordance of alterations of rs-fMRI indices in MDD with SI. In this study, we aimed to explore the variability and concordance of alterations of rs-fMRI indices in MDD with SI. <br><br>METHODS: A sliding window analysis was performed among 36 MDD patients with SI, 66 MDD patients without SI (NSI), and 50 healthy controls (HCs). Furthermore, the correlation between voxel-wise concordance and cognitive function was examined in the SI group. <br><br>RESULTS: The SI group had a lower dynamics degree centrality (dDC) value than the NSI group in left inferior occipital gyrus, and a lower voxel mirrored homotopic connectivity (dVMHC) value than the NSI group in the right and left inferior occipital gyrus. The mean values of volume wise concordance of HCs group shown higher than SI group and NSI group. SI group revealed decreased voxel-wise concordance in right cerebellum, left fusiform gyrus, left lingual gyrus, right middle temporal gyrus, left postcentral gyrus, and right supplementary motor area compared to NSI group. Moreover, the voxel-wise concordance of left middle occipital gyrus was negatively correlated with verbal learning and memory and working memory in the SI group. LIMITATION: This is a cross-sectional analysis, limiting causal inferences. <br><br>CONCLUSIONS: The abnormal voxel-wise concordance of left middle occipital gyrus could be useful in understanding the pathophysiology of MDD patients with SI.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2022.08.122
ID  - ref1
ER  -