TY  - JOUR
PY  - 2024//
TI  - Omics approaches to investigate the pathogenesis of suicide
JO  - Biological psychiatry
A1  - Berretta, Sabina
A1  - Zody, Michael
A1  - Vallender, Eric J.
A1  - Punzi, Giovanna
A1  - Martinowich, Keri
A1  - Gürsoy, Gamze
A1  - Pantazopoulos, Harry
A1  - Jabbi, Mbemba
A1  - Zhu, Chenxu
A1  - Sing, Tarjinder
A1  - Marenco, Stefano
A1  - Kleinman, Joel E.
A1  - Hyde, Thomas M.
A1  - Xiao, Yang
A1  - Lehner, Thomas
A1  - Turecki, Gustavo
A1  - Lewis, David A.
A1  - Roussos, Panagiotis
A1  - Boldrini, Maura
A1  - Mann, J. John
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Suicide is the second leading cause of death in U.S. adolescents and young adults, and generally associated with a psychiatric disorder. Suicidal behavior has a complex etiology and pathogenesis. Moderate heritability suggests genetic causes. Associations between childhood and recent life adversity indicate contributions from epigenetic factors. Genomic contributions to suicide pathogenesis remain largely unknown. This paper is based on a workshop held to design strategies to identify molecular drivers of suicide neurobiology that would be putative new treatment targets. The panel determined that, while bulk tissue studies provide comprehensive information, single-nucleus approaches identifying cell-type specific changes are needed. While single nuclei techniques lack information on cytoplasm, processes, spines, and synapses, spatial multiomic technologies on intact tissue detect cell alterations specific to brain tissue layers and subregions. Because suicide has genetic and environmental drivers, multiomic approaches combining cell-type specific epigenome, transcriptome, and proteome provide a more complete picture of pathogenesis. To determine the direction of effect of suicide risk gene variants on RNA and protein expression, and how these interact with epigenetic marks, single nuclei and spatial multiomics quantitative trait loci maps should be integrated with whole genome sequencing and genome-wide association databases. The workshop concluded with the recommendation for the formation of an international suicide biology consortium that will bring together brain banks and investigators with expertise in cutting-edge omics technologies to delineate the biology of suicide and identify novel potential treatment targets to be tested in cellular and animal models for drug and biomarkers discovery, to guide suicide prevention.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/10.1016/j.biopsych.2024.05.017
ID  - ref1
ER  -