TY - JOUR
PY - 1999//
TI - 4 Case of Rhabdomyolysis due to Doxylamine Intoxication
JO - Korean journal of nephrology
A1 - Yoo, Jong-Hoon
A1 - Choi, Eui-Hyuk
A1 - Lee, Jeong-Seok
A1 - Hong, Su-Hee
A1 - Koun, Hyoung-Ju
A1 - Lee, Mu-Yeul
A1 - Park, Young-U
A1 - Lee, Chul-Ho
A1 - Seo, Bo-Jeong
A1 - Lee, Dong-Yun
A1 - Lee, Jun-Sang
SP - 494
EP - 500
VL -
IS -
N2 - Doxylamine is common over-the-counter sleep preparations & frequently involved in overdoses. The clinical course is dominated by the anticholinergic effects, including central nervous system & autonomic effects. We report 4 cases of suicide attempts in adults where ingestion of the doxylamines were complicated by rhabdomyolysis. They ingested doxylamines variable amount & were carried to emergency department. They complained gastrointestinal or central nervous system symptoms. Gastric lavages & administrations of activated charcoal were done. Creatine phosphok inase levels were normal or markedly elevated on arrival, but peaked several days later. Serum creatinine levels were normal. 99mTc-MDP bone scans were showed increased muscle labelling at the regions of muscle injury. They were treated with hydration, urine alkalinization, & supportive measures in hospital. On considering cause of rhabdomyolysis, our patients did not show any evidence of viral illness or coingestion of other potential myopathic toxins to support a secondary cause of rhabdomyolysis. The mechanism of rhabdomyolysis in cases of doxylamine overdose seems to be a direct toxic effect of the drug on striated muscle, but the exact mechanism is not clear. In all cases where such overdoses are suspected, consideration should be given to obtaining a urinalysis & a creatine phosphokinase level on arrival & creatine phosphokinase levels are carefully followed. Primary detoxication included gastric lavage & administration of activated charcoal. The patient's urine output & renal function should be closely monitored. Language: ko
LA - ko
SN - 1225-0015
UR - http://dx.doi.org/
ID - ref1
ER -