TY  - JOUR
PY  - 2022//
TI  - Plasma Apolipoprotein-AIV Downregulated in Patients with Major Depressive Disorder having Suicidal Ideation Compared to those without Suicidal Ideation
JO  - Current Proteomics
A1  - Mathew, B.
A1  - Srinivasan, K.
A1  - Pradeep, J.
A1  - Thomas, T.
A1  - Mandal, A.K.
SP  - 226
EP  - 231
VL  - 19
IS  - 3
N2  - BACKGROUND: Identification of a peripheral biological marker might aid in identifying patients at high risk of attempting suicide and might help in effective early intervention. <br><br>OBJECTIVE: In the present study, we extend the findings of our previous multidimensional pro-teomics study by examining the levels of plasma Apolipoprotein-AIV in patients diagnosed with major depression with and without suicidal ideation compared to age and gender-matched controls. <br><br>METHODS: Using the mass spectrometry platform, we quantified the levels of plasma Apolipopro-tein-AIV in patients with major depressive disorder with and without suicidal ideation compared to matched controls with isotope-labelled peptides-based quantitative proteomics approach. <br><br>RESULTS: The targeted quantitative proteomics approach with isotope-labelled peptides showed that plasma Apolipoprotein-AIV was significantly downregulated in depressed patients having suicidal ideation 1.45 (CI:1.11-1.90) compared to those without suicidal ideation 0.88 (CI:0.77-1.003). <br><br>CONCLUSION: These findings extend our earlier observation of downregulation of plasma Apolipo-protein-AIV in patients with suicidal attempts to depressed patients with suicidal ideation. The con-sistent downregulation of plasma Apolipoprotein-AIV observed in both the proteomics studies suggests Apolipoprotein-AIV might be a plasma-based biomarker for suicidal behaviour. © 2022 Bentham Science Publishers.<p /> <p>Language: en</p>
LA  - en
SN  - 1570-1646
UR  - http://dx.doi.org/10.2174/1570164618666211104151005
ID  - ref1
ER  -