TY  - JOUR
PY  - 2021//
TI  - Selected ion flow tube-mass spectrometry (sift-ms) as an alternative to gas chromatography/mass spectrometry (gc/ms) for the analysis of cyclohexanone and cyclohexanol in plasma
JO  - ACS Omega
A1  - Hastie, C.
A1  - Thompson, A.
A1  - Perkins, M.
A1  - Langford, V.S.
A1  - Eddleston, M.
A1  - Homer, N.Z.M.
SP  - 32818
EP  - 32822
VL  - 6
IS  - 48
N2  - Self-poisoning with professional agricultural pesticide products is responsible for about 20% of global suicide, with most cases occurring in South Asia and China. Treatment of severe poisoning involves long-term intensive clinical care and is often unsuccessful. Solvent co-formulants (such as cyclohexanone) also contribute to mortality themselves or via more toxic metabolic products (such as cyclohexanol). Faster detection of co-formulants could aid earlier identification of pesticide poisoning and faster intervention, reducing mortality. Conventional analysis of volatiles in blood uses headspace (HS)-GC/MS. This paper evaluates SIFT-MS, a direct MS technique that provides higher sample throughput than GC/MS, as a potential tool for cyclohexanone and cyclohexanol analysis in plasma. Both instruments were calibrated using a conventional approach prior to analysis of each porcine plasma sample on both instruments. Comparative data were evaluated using Bland-Altman plots, demonstrating that the techniques were in good agreement. Compared with GC/MS, SIFT-MS provides fourfold higher sample throughput and shows great promise as an alternative analytical tool. ©<p /> <p>Language: en</p>
LA  - en
SN  - 2470-1343
UR  - http://dx.doi.org/10.1021/acsomega.1c03827
ID  - ref1
ER  -