TY  - JOUR
PY  - 2021//
TI  - Gender differences in the clinical course of depression in bipolar disorder
JO  - Nevrologiya, Neiropsikhiatriya, Psikhosomatika
A1  - Tyuvina, N.A.
A1  - Stolyarova, A.E.
A1  - Morozova, V.D.
A1  - Verbitskaya, M.S.
SP  - 47
EP  - 55
VL  - 13
IS  - 2
N2  - OBJECTIVE: to investigate gender differences in patients with depression and bipolar disorder (BPAD) and their impact on the clinical course of the disease. Patients and methods. 50 women and 50 men with bipolar disorder (BPAD) (F31 according to the International Classification of Diseases, 10th revision - ICD-10) were examined using a specially developed survey. Patients' symptoms were assessed in accordance with the diagnostic criteria of affective disorders according to ICD-10 and DSM-V, MADRS (Montgomery-Asberg Depression Rating Scale) and Q-LES-Q-SF (Scoring the Quality of Life Enjoyment and Satisfaction Questionnaire). <br><br>RESULTS and discussion. Gender differences in the clinical course of BPAD were revealed. In men the disease usually starts with a mania phase followed by a marked mood increase in BPAD-I, a shorter period before the first mania (hypomania) if the onset is with the depression phase, mood swings and substance use disorders in puberty, which makes the diagnosis easier. In women BPAD diagnosis may be harder due to higher frequency of BPAD-II, clinical presentation with depression, longer period before the first mania (hypomania). Therefore, the most important clinical markers of BPAD in women include the early onset of the disease, its association with neurohormonal factors, history of affective variability, substance use disorders, schizophrenia, hereditary or comorbid eating disorder in puberty or later in life. The most common clinical features during the depression phase in men include: seasonal fluctuation (worsening of symptoms in autumn and winter) and diurnal variations (improvement of symptoms in the evening), numbed emotions, depersonalization-derealization syndrome, decreased libido, difficulty in falling asleep and increased appetite and/or body mass, comorbid depression, panic attacks and alcohol and substance abuse. The depression in women with BPAD is characterized by a higher prevalence of apathy, tearfulness, self-harm, body dysmorphic disorder, decreased appetite. Both male and female patients with depression and BPAD have a high level of anxiety, presence of psychomotor retardation, self-accusation and irritancy, 10% had atypical features according to the DSM-V criteria. Women have a higher proportion of depressive episodes (including rapid cycling BPAD) and a higher risk of suicidal behavior, and men, due to a higher frequency of manic phases, change partners and have a history of divorce significantly more often. <br><br>CONCLUSION. The revealed features of psychopathological symptoms, comorbid disorders, the course of the disease and correlations between individual characteristics and factors due to gender differences, can be used as markers of bipolarity, which will allow to diagnose BPAD earlier and more accurately and prescribe adequate therapy. © 2021 Ima-Press Publishing House. All rights reserved.<p /> <p>Language: en</p>
LA  - en
SN  - 2074-2711
UR  - http://dx.doi.org/10.14412/2074-2711-2021-2-47-55
ID  - ref1
ER  -