TY  - JOUR
PY  - 2018//
TI  - Fast effect of buprenorphine on opioid-dependent patients with suicidal ideation: A novel approach
JO  - International journal of high risk behaviors and addiction
A1  - Ahmadi, J.
A1  - Jahromi, M.S.
SP  - 
EP  - 
VL  - 7
IS  - 2
N2  - BACKGROUND: Buprenorphine is usually administered tomanageopioid use disorderandpain syndromes. It could be a proper treatment option for suicidality, resistant depression, self-destructive behavior, and anxiety. Buprenorphine has a considerable abuse potential that confines its administration in patients committing suicide with a background of substance abuse. <br><br>OBJECTIVES: The current study aimed to clarify the influence of different doses of buprenorphine on opioid-dependent patients committing suicide over a 2-day period in a randomized, clinical trial (RCT). <br><br>PATIENTS AND METHODS: Patients were randomly assigned into 3 groups. Twenty-three suicidal male patients whomet the DSM-5 (diagnostic and statistical manual of mental disorders) criteria for opioid dependence and sought treatment were recruited. Patients randomly received 32, 64, or 96 mg of buprenorphine as a single high-dose only and were hospitalized in a psychiatric inpatient ward. Out of the 23 patients, 9 (39.2%), 8 (34.8%), and 6 (26%) received 32, 64, and 96mgof buprenorphine, respectively. Psychometric assessment was performedusing the Beck scale for suicidal ideation (BSSI) and interview. All patients completed the 2-day treatment period. The results indicated a significant decrease in BSSI scores in each of the 3 groups (P < 0.05), but there was no difference in the outcome between the groups (P = 0.30). <br><br>CONCLUSIONS: The current study results indicated that a single high-dose of buprenorphine could provide a speedy and safe means to treat suicidality in opioid-dependent patients. © 2018, International Journal of High Risk Behaviors and Addiction.<p /> <p>Language: en</p>
LA  - en
SN  - 2251-8711
UR  - http://dx.doi.org/10.5812/ijhrba.57510
ID  - ref1
ER  -