TY  - JOUR
PY  - 2018//
TI  - Advances in NMDA receptors-related antidepressants
JO  - Chinese Pharmacological Bulletin
A1  - Guang-Fen, Z.
A1  - Jian-Jun, Y.
SP  - 1
EP  - 4
VL  - 34
IS  - 1
N2  - Recent studies have demonstrated that ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, can produce rapid and effective antidepressant actions, especially for patients with treatment-resistant depression, bipolar disorder and suicide idea. However, the clinical application of ketamine is limited by its psychotomimetic adverse reactions and potential a-buse. Therefore, development of novel ketamine-like antidepressant agents with fewer side effects is actively investigated cur-rently. The latest researches indicate that the metabolites of ket-amine, the S-ketamine/R-ketamine and the modulators of NMDA receptor subunits can exert safe and effective antidepressant actions. In this article, the research advance in NMDA recep-tors-related antidepressants mentioned above will be reviewed. © 2018 Publication Centre of Anhui Medical University. All rights reserved.<p /> <p>Language: zh</p>
LA  - zh
SN  - 1001-1978
UR  - http://dx.doi.org/10.3969/j.issn.1001-1978.2018.01.001
ID  - ref1
ER  -