TY  - JOUR
PY  - 2016//
TI  - Childhood trauma and bipolar disorder: A previously neglected research area
JO  - Nervenheilkunde
A1  - Bauer, R.
A1  - Bauer, M.
SP  - 481
EP  - 484
VL  - 35
IS  - 7-8
N2  - Childhood physical abuse is associated with an increased risk for the development of substance dependency, psychotic disorders, depression and anxiety disorders. The role of childhood trauma in the etiology and course of bipolar disorder has been a neglected research area. Due to more recent research in this area, there is increasing evidence that childhood trauma represent a risk factor for bipolar disorder. For example, a case-control study assessing more than 200 bipolar patients showed that multiple traumas (eg, emotional and sexual abuse, emotional neglect) are more frequent in patients with bipolar disorder than in healthy controls. In a recent large-scale study, earlier age at onset of bipolar illness, suicide attempts, rapid cycling, and an increased number of depressive episodes each had significant associations with at least 1 subtype of childhood trauma (emotional abuse, sexual abuse, and emotional neglect). Multivariate analyses investigating trauma variables together showed that both emotional and sexual abuse were independent predictors of lower age at onset and history of suicide attempts while sexual abuse was the strongest predictor of rapid cycling. The main clinical implication is to systematically assess childhood trauma in patients with bipolar disorders, particularly in those with an instable course. The challenge is to fill the gap between clinical research and routine practice, since recommendations for managing this specific population are lacking. © Schattauer 2016.<p /> <p>Language: de</p>
LA  - de
SN  - 0722-1541
UR  - http://dx.doi.org/10.1055/s-0037-1616409
ID  - ref1
ER  -