TY  - JOUR
PY  - 2011//
TI  - Connection re-established: Neurotransmission between the medial prefrontal cortex and serotonergic neurons offers perspectives for fast antidepressant action
JO  - Neuropsychiatry (London)
A1  - Etiévant, A.
A1  - Lambs-Seas, L.
A1  - Abrial, E.
A1  - Bétry, C.
A1  - Haddjeri, N.
A1  - Lucas, G.
SP  - 165
EP  - 177
VL  - 1
IS  - 2
N2  - The search for fast-acting antidepressants has been a major challenge in neuropsychopharmacology for many years. Although the involvement of serotonin (5-HT) in the mechanisms of action of classical antidepressants has been clearly established, the delayed onset of action of these drugs prompted several authors to propose alternative targets in order to achieve a more rapid relief of symptoms in depressed patients. However, recent studies indicate that it may be possible to elaborate fast-acting antidepressant strategies based on 5-HT, provided that such strategies would directly target 5-HT neuron electrical activity. Furthermore, glutamatergic pyramidal neurons projecting from the medial prefrontal cortex to the dorsal raphé appear to play a critical role. This article presents some of the data that support this hypothesis, including results from medial prefrontal cortex deep-brain stimulation studies, as well as those related to treatments with 5-HT4 agonists and 5-HT7 antagonists. © 2011 Future Medicine Ltd.<p /> <p>Language: en</p>
LA  - en
SN  - 1758-2008
UR  - http://dx.doi.org/10.2217/npy.11.9
ID  - ref1
ER  -