TY  - JOUR
PY  - 2010//
TI  - The potential association between isotretinoin treatment, depression and suicidal behaviors: A review
JO  - Current psychiatry reviews
A1  - Padgett, C.L.
SP  - 234
EP  - 243
VL  - 6
IS  - 4
N2  - Since 1982 isotretinoin has been implicated in numerous reports that describe depression, behavioral change and suicidality in patients. Several epidemiological studies have investigated the association suggested by these reports. <br><br>RESULTS have varied. Other research has attempted to establish a plausible biological mechanism associating isotretinoin with these behavioral changes. Current research has focused on the hippocampus. It is possible that individuals that experience these side effects have a predisposition to these outcomes. There is need for additional prospective studies and randomized clinical trials that consider both the presence of a potential mechanism as well as the methodological weaknesses in the current literature. Additional basic science research also needs to further evaluate this potential mechanism. © 2010 Bentham Science Publishers Ltd.<p /> <p>Language: en</p>
LA  - en
SN  - 1573-4005
UR  - http://dx.doi.org/10.2174/157340010793499413
ID  - ref1
ER  -