TY  - JOUR
PY  - 2010//
TI  - Medical and psychiatric outcomes for patients transplanted for acetaminophen-induced acute liver failure: A case-control study
JO  - Liver international
A1  - Karvellas, C.J.
A1  - Safinia, N.
A1  - Auzinger, G.
A1  - Heaton, N.
A1  - Muiesan, P.
A1  - O'Grady, J.
A1  - Wendon, J.
A1  - Bernal, W.
SP  - 826
EP  - 833
VL  - 30
IS  - 6
N2  - BACKGROUND: Acetaminophen-induced hepatotoxicity is the most common cause of acute liver failure (ALF) in the UK. Patients often consume the drug with suicidal intent or with a background of substance dependence. Aims and methods: We compared the severity of pretransplant illness, psychiatric co-morbidity, medical and psychosocial outcomes of all patients who had undergone liver transplantation (LT) emergently between 1999-2004 for acetaminophen-induced ALF (n=36) with age- and sex-matched patients undergoing emergent LT for non-acetaminophen-induced ALF (n=35) and elective LT for chronic liver disease (CLD, n=34). <br><br>RESULTS: Acetaminophen-induced ALF patients undergoing LT had a greater severity of pre-LT illness reflected by higher Acute Physiology and Chronic Health Evaluation II scores and requirement for organ support compared with the other two groups. Twenty (56%) acetaminophen-induced ALF patients had a formal psychiatric diagnosis before LT (non-acetaminophen-induced ALF=0/35, CLD=2/34; P<0.01 for all) and nine (25%) had a previous suicide attempt. During follow-up (median 5 years), there were no significant differences in rejection (acute and chronic), graft failure or survival between the groups (acetaminophen-induced ALF 1 year 87%, 5 years 75%; non-acetaminophen-induced ALF 88%, 78%; CLD 93%, 82%: P>0.6 log rank). Two acetaminophen-induced ALF patients reattempted suicide post-LT (one died 8 years post-LT). <br><br>CONCLUSIONS: Despite a high prevalence of psychiatric disturbance, outcomes for patients transplanted emergently for acetaminophen-induced ALF were comparable to those transplanted for non-acetaminophen-induced ALF and electively for CLD. Multidisciplinary approaches with long-term psychiatric follow-up may contribute to low post-transplant suicide rates seen and low rates of graft loss because of non-compliance. © 2010 John Wiley & Sons A/S.<p /> <p>Language: en</p>
LA  - en
SN  - 1478-3223
UR  - http://dx.doi.org/10.1111/j.1478-3231.2010.02243.x
ID  - ref1
ER  -