TY  - JOUR
PY  - 2007//
TI  - Gemfibrozil ingestions reported to Texas poison control centers, 2000-2005
JO  - Journal of toxicology and environmental health - Part A
A1  - Forrester, Mathias B.
SP  - 2027
EP  - 2032
VL  - 70
IS  - 24
N2  - Review of the literature failed to identify any information on potentially adverse ingestions of the cholesterol-lowering drug gemfibrozil (GEM) reported to poison control centers. Data from Texas poison control centers were used to describe the pattern of isolated GEM ingestions reported during 2000-2005. A total of 118 cases were identified. The mean maximum dose ingested was 2407 mg (range 300-18,000 mg) or 3.3 tablets/capsules (range 1-30 tablets/capsules). The patient was male in 55% of the cases. The most common circumstances of the exposure were unintentional therapeutic error (49%), general unintentional (34%), and suspected attempted suicide (11%). The management site was on site (84%), already at/en route to a health care facility (10%), referred to a health care facility (5%), and other (2%). The ingestion considered potentially toxic in 3% of the cases and no deaths were reported. A specific adverse clinical effect was listed for 9% of the cases, being gastrointestinal (5%), neurological (3%), or cardiovascular (1%). A specific treatment was listed for 54% of the cases, most frequently decontamination by dilution (39%) or food (15%). Potentially adverse isolated GEM ingestions reported to poison control centers generally do not involve serious medical outcomes and are successfully managed at home with a favorable outcome.<p />  <p>Language: en</p>
LA  - en
SN  - 1528-7394
UR  - http://dx.doi.org/10.1080/15287390701601194
ID  - ref1
ER  -