TY  - JOUR
PY  - 2008//
TI  - Progress in the development of early-onset antidepressants
JO  - Chinese Pharmacological Bulletin
A1  - Xue, R.
A1  - Zhang, Y.-z.
A1  - Zou, L.-b.
SP  - 1558
EP  - 1561
VL  - 24
IS  - 12
N2  - Existing antidepressants exhibit delayed onset of action, which can decrease the compliance of the patients and enhance the risk of suicide. How to produce early-onset antidepressants with higher efficacy and lower adverse reactions has become a crucial point in the research of antidepressants. It has been demonstrated that selective 5-HT1A antagonist, α2 antagonist and 5-HT2A antagonist can accelerate the response of classic antidepressants. Furthermore,5-HT/NE dual reuptake inhibitor and 5-HT/NE/DA triple reuptake inhibitor can also produce early onset of action. Here several reasons for the delayed onset of action and the progress in the development of early-onset antidepressants are reviewed.<p /> <p>Language: zh</p>
LA  - zh
SN  - 1001-1978
UR  - http://dx.doi.org/
ID  - ref1
ER  -