TY  - JOUR
PY  - 2008//
TI  - Clinical significance of post-dialysis plasma concentrations of atrial natriuretic peptide and brain natiuretic peptide as long-term survival predictors in hemodialysis patients: 15-year follow up study
JO  - Dokkyo journal of medical sciences
A1  - Teranishi, M.
A1  - Hirata, Y.
A1  - Miyashita, K.
A1  - Suzuki, M.
A1  - Hurudera, R.
A1  - Saitou, K.
A1  - Ishii, K.
A1  - Goto, A.
A1  - Nishiyama, K.
A1  - Matsuoka, H.
SP  - 71
EP  - 78
VL  - 35
IS  - 2
N2  - This study was designed to clarify the clinical significance of post-dialysis plasma vasoactive substances including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), plasma renin activity (PRA) and noradrenaline (PNA) as a survival predictor in chronic hemo-dialysis (HD) patients. Immediately after HD, blood samples were collected for the measurements of serum albumin, ANP, BNP, PRA and PNA in 52 HD patients. During 15-year follow-up period 43 patients died: 40 of diseases, 2 accident, 1 suicide. Patients were divided into two groups using the median of their age and clinical and laboratory variables. Kaplan - Meier survival analysis revealed that the groups of older age, higher plasma ANP and BNP concentration had significantly lower survival rates as compared with each counterpart (p < 0.001, p = 0.006, p = 0.039, respectively). Univariate and multivariate Cox proportional hazard regression analyses were used to assess the potential association of their age, and clinical and laboratory variables with a survival rate. As a result of Univariate Cox hazard analysis, age, cardiothoracic ratio (CTR), and plasma ANP, and BNP concentrations had significant relationship with overall mortality (p < 0.001, p = 0.011, p = 0.003, and p = 0.002, respectively). However, stepwise multivariate analysis revealed that the significant relationship with overall mortality was shown for their age (p < 0.001) and BNP (p = 0.041). These results demonstrated that the post-dialysis plasma BNP concentration was an independent risk factor for long-term survival and the post-dialysis plasma ANP concentration was also an important risk factor next to the BNP concentration.<p /> <p>Language: ja</p>
LA  - ja
SN  - 0385-5023
UR  - http://dx.doi.org/
ID  - ref1
ER  -