TY  - JOUR
PY  - 1999//
TI  - Suicide and depression: Mechanisms associated with A2A-adrenoceptors
JO  - Médecine et hygiène
A1  - Garcia-Sevilla, J.A.
A1  - Walzer, C.
A1  - La Harpe, R.
A1  - Eytan, A.
A1  - Guimón, J.
SP  - 1744
EP  - 1749
VL  - 57
IS  - 2269
N2  - Suicide and depression are associated with an increased density of a2-adrenoceptors in specific regions of the human brain. The function of these inhibitory receptors involves various regulatory proteins (the G inhibitory protein Gail/2 and the GRK2 kinase), which work in concert with the receptors. Increased levels of a2A-adrenoceptors, Gail/2 proteins, and membrane-associated GRK2 were found in the prefrontal cortex of suicide victims and antidepressant-free depressed suicide victims. In these two groups, then were significant correlations between the levels of GRK2 (dependent variable) and those a2A-adrenoceptors and Gail/2 proteins (independent variables). Antemortem antidepressant treatment was associated with a significant reduction in the levels of Gail/2 proteins, but with modest decreases in the levels of a2A-adrenoceptors and GRK2 in the brains of depressed suicide victims. Taken altogether, these results support the existence of supersensitive a2A-adrenoceptors in subjects with major depression.<p /> <p>Language: fr</p>
LA  - fr
SN  - 0025-6749
UR  - http://dx.doi.org/
ID  - ref1
ER  -