TY  - JOUR
PY  - 1997//
TI  - Report of a case of intoxication by flecainide
JO  - Urgences médicales : revue européenne d'oxyologie
A1  - Andre, P.
A1  - Berginiat, N.
A1  - Triaureau, G.
A1  - Lalande, G.
SP  - 205
EP  - 207
VL  - 16
IS  - 5
N2  - Some poisonings with antiarrhythmic drugs still have a poor prognosis, especially in cases of voluntary massive ingestion, despite progress in intensive care facilities and procedures. This case report concerns the suicidal intoxication of a 39-year-old female without any medical history who ingested six grams of flecainide (Vaughan-Williams class lc), probably associated with nadolol (beta-adrenergic blocking agent). Despite rapid intensive care, the outcome was unsuccessful, featuring a cardiac shock without response to drugs and severe cardiac rhythm and conduction problems. Flecainide blood level (1.9 mg/L) showed a toxic concentration, but was uncorrelated with the clinical severity and the ingested dose of six grams. We suggest the associated intoxication with a beta-adrenergic blocking agent may have been an aggravating factor hastening the lethal outcome.<p /> <p>Language: fr</p>
LA  - fr
SN  - 0923-2524
UR  - http://dx.doi.org/10.1016/S0923-2524(97)89779-2
ID  - ref1
ER  -