TY  - JOUR
PY  - 1997//
TI  - Determination of hepatitis markers in cadavers
JO  - Romanian journal of legal medicine
A1  - Drugescu, N.
A1  - Curca, C.
A1  - Girbea, G.
A1  - Constantinescu, A.
SP  - 128
EP  - 136
VL  - 5
IS  - 2
N2  - Determination of hepatitis markers in cadavers. We have studied in 58 randomly selected cadavers the presence of various types of parenterally transmitted hepatitis viruses (B, C and D), our main objective being the evaluation of the professional risk associated with forensic autopsies. Each case have been tested for the presence of the following markers: AgHBs, AgHBe, anti-HBs, total anti-HBc, total anti-HCV and total anti-Delta. This set of tests, cover all the immunobiological variants of a vital hepatitis that can be relied upon in cadaver serum. As AgHBs positive was found in 22.41% of the cases (either recent infection or chronic carrier) and in 23.59% AgHBs was negative but AgHbc was positive (the 'anticore window effect' explains why the determination of only AgHBs do not estimate correctly the infectious risk), it results that 55% of all cases presented a serious risk of B hepatitis infection. D hepatitis was found in 1.72% as coinfection. An unexpected observation was that only 27% of suicides were virus hepatitis B or C free, although the number of cases is insufficient for statistic processing the authors believe that recent hepatic viral infections B or C might play a part in triggering the suicidal act. The differentiation between recent B viral infection and chronic carrier status cannot be made based only on postmortem serologic determination (dynamic determinations are impossible); it should associate microscopic investigation of the liver. Delta infection can be diagnosed in cadaver using anti-HBc IGM.<p /> <p>Language: romanian</p>
LA  - 
SN  - 1221-8618
UR  - http://dx.doi.org/
ID  - ref1
ER  -