TY  - JOUR
PY  - 2022//
TI  - Postpartum depression and major depressive disorder: the same or not? Evidence from resting-state functional MRI
JO  - Psychoradiology
A1  - Cheng, Bochao
A1  - Guo, Yi
A1  - Chen, Xijian
A1  - Lv, Bin
A1  - Liao, Yi
A1  - Qu, Haibo
A1  - Hu, Xiao
A1  - Yang, Haoxiang
A1  - Meng, Yajing
A1  - Deng, Wei
A1  - Wang, Jiaojian
SP  - 121
EP  - 128
VL  - 2
IS  - 3
N2  - BACKGROUND: Although postpartum depression (PPD) and non-peripartum major depressive disorder (MDD) occurring within and outside the postpartum period share many clinical characteristics, whether PPD and MDD are the same or not remains controversial. <br><br>METHODS: The current study was devoted to identify the shared and different neural circuits between PPD and MDD by resting-state functional magnetic resonance imaging data from 77 participants (22 first-episodic drug-naïve MDD, 26 drug-naïve PPD, and 29 healthy controls (HC)). <br><br>RESULTS: Both the PPD and MDD groups exhibited higher fractional amplitude of low-frequency fluctuation (fALFF) in left temporal pole relative to the HC group; the MDD group showed specifically increased degree centrality in the right cerebellum while PPD showed specifically decreased fALFF in the left supplementary motor area and posterior middle temporal gyrus (pMTG_L), and specifically decreased functional connectivities between pMTG and precuneus and between left subgeneual anterior cingulate cortex (sgACC_L) and right sgACC. Moreover, sgACC and left thalamus showed abnormal regional homogeneity of functional activities between any pair of HC, MDD, and PPD. <br><br>CONCLUSIONS: These results provide initial evidence that PPD and MDD have common and distinct neural circuits, which may facilitate understanding the neurophysiological basis and precision treatment for PPD.<p />  <p>Language: en</p>
LA  - en
SN  - 2634-4416
UR  - http://dx.doi.org/10.1093/psyrad/kkac015
ID  - ref1
ER  -