TY  - JOUR
PY  - 2024//
TI  - Distinct effects of first-episode and recurrent major depression disorder on brain changes related to suicidal ideation: evidence from the REST-meta-MDD Project
JO  - Journal of affective disorders
A1  - Sun, Fenfen
A1  - Yan, Jin
A1  - Pang, Jianan
A1  - Song, Mingqiao
A1  - Wang, Minmin
A1  - Huang, Tianming
A1  - Zhao, Zhiyong
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Significant differences in clinical manifestations between first-episode and recurrent major depression disorder (FE-MDD/R-MDD) have been demonstrated in previous studies, including the degree of suicide attempt. However, the potential brain mechanism underlying the effect of depressive episode frequency on suicidal ideation (SI) remains unclear. <br><br>METHODS: In this study, 102 patients with FE-MDD (SI/non-SI: N = 70/32) and 71 matched normal controls (NCs), as well as 75 patients with R-MDD (SI/non-SI: N = 37/38) and 49 matched NCs were screened from the Chinese REST-meta-MDD consortium. T1-weighted and resting-state fMRI images were used to calculate gray matter volume (GMV) and fractional amplitude of low-frequency fluctuations (fALFF), respectively. <br><br>RESULTS: Group comparisons revealed that FE-MDD showed changes only in GMV, while R-MDD showed changes in both GMV and fALFF compared to NCs. SI-specific GMV decreases were observed in the right cerebellum, superior marginal gyrus, and left middle temporal gyrus in FE-MDD patients, while SI-specific fALFF decreases were observed in bilateral superior frontal gyrus and increases in bilateral cerebellum and left parahippocampal gyrus in R-MDD patients. Moreover, a negative correlation was found between GMV value in right cerebellum and HAMD score. <br><br>CONCLUSIONS: These findings suggest that first-episode and recurrent MDD show different effects on brain structure and function in patients with SI, providing a potential explanation for the distinct clinical manifestations of MDD patients from a brain mechanisms perspective.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2024.01.213
ID  - ref1
ER  -