TY  - JOUR
PY  - 2023//
TI  - Progesterone attenuates the stress response in individuals with alcohol dependence and post-traumatic stress disorder - a pilot study
JO  - Journal of dual diagnosis
A1  - Ralevski, Elizabeth
A1  - Newcomb, Jenelle
A1  - Pisani, Emily
A1  - DeNegre, Diana
A1  - Peltier, MacKenzie
A1  - Jane, Jane Serrita
A1  - Yoon, Gihyun
A1  - Petrakis, Ismene
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: Evidence from laboratory studies suggests that progesterone may be effective in reducing stress and craving, and may improve cognitive performance in smokers and individuals with cocaine dependence. The objective of this study was to examine if progesterone would attenuate stress-induced craving, anxiety, affect and physiological measures, as well as improve stress-induced cognitive performance (processing speed and selective attention) in individuals diagnosed with alcohol use disorder (AUD) and post traumatic stress disorder (PTSD).<br><br>METHODS: This laboratory study included (n = 13) participants who were diagnosed with current AUD and PTSD who were randomly assigned to recive either progesterone (200mg bid) or placebo in identical looking capsules for 3 days. On the fourth day they completed a laboratory session. In the morning of the test session, they received the last dose of medication and completed the rest of the laboratory procedures. The procedures included presentation in random order of personalized trauma and neutral scripts with relaxation in between. Main outcomes included measure of craving, anxiety, affect and cognitive performance.<br><br>RESULTS: Consistent with other research, trauma scripts produced significantly greater increases in craving, anxiety and negative affect when compared with neutral scripts. Progesterone significantly reduced stress-induced symptoms of craving, anxiety, fear, anger and sadness but had no effect on positive emotions (joy, relaxation). Progesterone was effective in ameliorating stress-induced decreases in cognitive performance.<br><br>CONCLUSIONS: The findings from this study demonstrate that progesterone can be effective in reducing stress-induced craving, anxiety and negative affect in a laboratory setting in individuals with comorbid AUD and PTSD. Interestingly, progesterone also improved cognitive performance. These findings require replication in a larger clinical trial and may have implications for treatment among individuals with AUD and PTSD.    This study was registered as NCT02187224, at www.clinicaltrials.gov.<p />  <p>Language: en</p>
LA  - en
SN  - 1550-4263
UR  - http://dx.doi.org/10.1080/15504263.2023.2294989
ID  - ref1
ER  -