TY  - JOUR
PY  - 2023//
TI  - Indirect effect of impulsivity on suicide risk through self-esteem and depressive symptoms in a population with treatment-resistant depression: a FACE-DR study
JO  - Journal of affective disorders
A1  - Salles, Juliette
A1  - Stephan, Florian
A1  - Molière, Fanny
A1  - Bennabi, Djamila
A1  - Haffen, Emmanuel
A1  - Bouvard, Alexandra
A1  - Walter, Michel
A1  - Allauze, Etienne
A1  - Llorca, Pierre Michel
A1  - Genty, Jean Baptiste
A1  - Leboyer, Marion
A1  - Holtzmann, Jérôme
A1  - Nguon, Anne Sophie
A1  - d'Amato, Thierry
A1  - Rey, Romain
A1  - Horn, Mathilde
A1  - Vaiva, Guillaume
A1  - Fond, Guillaume
A1  - Richieri, Raphaëlle
A1  - Hennion, Vincent
A1  - Etain, Bruno
A1  - El-Hage, Wissam
A1  - Camus, Vincent
A1  - Courtet, Philippe
A1  - Aouizerate, Bruno
A1  - Yrondi, Antoine
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - INTRODUCTION: Suicide is a major health issue. Its prevalence is particularly high in subjects presenting major depression disorder (MDD), making this a key suicide-related risk factor. Suicide attempts in severe forms of MDD were assumed to be linked to impulsivity and loss of control. Nevertheless, we failed to find data specifically investigating the link between impulsivity and suicide risk in treatment-resistant depression (TRD). This study seeks to review this relationship. <br><br>METHOD: Patients were recruited for a prospective cohort. Suicide risk and impulsivity were assessed using the International Neuropsychiatric Interview and Barratt Impulsiveness Scale, Version 10, respectively, while the severity of depressive symptoms was assessed using the Montgomery-Asberg Depression Rating Scale, anxiety with the State-Trait Anxiety Inventory and childhood maltreatment using the Childhood Trauma Questionnaire. <br><br>RESULTS: 220 TRD patients were enrolled in the study. The impulsivity score was correlated with self-esteem, marital status, professional status and anxiety. There was no direct link to suicide risk. However, impulsivity was associated with self-esteem (coefficient: -0.24; p value 0.043) and depressive symptom severity (coefficient: 0.; p value 0.045). The suicide risk was significantly correlated with depressive symptom severity (coefficient = 0.38, p < 0.001) and self-esteem (coefficient = -0.34, p = 0.01). Considering these correlations, we postulated that the effect of impulsivity on suicide risk could be mediated by self-esteem in terms of depressive symptom severity and we finally found a relevant mediation model within impulsivity having an indirect effect on suicide risk by impacting self-esteem and depressive symptoms with anxiety also playing a significant role as a covariable. <br><br>CONCLUSION: We found that impulsivity could play an indirect role with the involvement of self-esteem and depressive symptoms and the contributing role of anxiety.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2023.11.063
ID  - ref1
ER  -