TY  - JOUR
PY  - 2023//
TI  - Sleep deprivation attenuates neural responses to outcomes from risky decision-making
JO  - Psychophysiology
A1  - Mao, Tianxin
A1  - Fang, Zhuo
A1  - Chai, Ya
A1  - Deng, Yao
A1  - Rao, Joy
A1  - Quan, Peng
A1  - Goel, Namni
A1  - Basner, Mathias
A1  - Guo, Bowen
A1  - Dinges, David F.
A1  - Liu, Jianghong
A1  - Detre, John A.
A1  - Rao, Hengyi
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Sleep loss impacts a broad range of brain and cognitive functions. However, how sleep deprivation affects risky decision-making remains inconclusive. This study used functional MRI to examine the impact of one night of total sleep deprivation (TSD) on risky decision-making behavior and the underlying brain responses in healthy adults. In this study, we analyzed data from N = 56 participants in a strictly controlled 5-day and 4-night in-laboratory study using a modified Balloon Analogue Risk Task. Participants completed two scan sessions in counter-balanced order, including one scan during rested wakefulness (RW) and another scan after one night of TSD. <br><br>RESULTS showed no differences in participants' risk-taking propensity and risk-induced activation between RW and TSD. However, participants showed significantly reduced neural activity in the anterior cingulate cortex and bilateral insula for loss outcomes, and in bilateral putamen for win outcomes during TSD compared with RW. Moreover, risk-induced activation in the insula negatively correlated with participants' risk-taking propensity during RW, while no such correlations were observed after TSD. These findings suggest that sleep loss may impact risky decision-making by attenuating neural responses to decision outcomes and impairing brain-behavior associations.<p />  <p>Language: en</p>
LA  - en
SN  - 0048-5772
UR  - http://dx.doi.org/10.1111/psyp.14465
ID  - ref1
ER  -