TY  - JOUR
PY  - 2023//
TI  - Steroid hormone-mediated regulation of sexual and aggressive behaviour by non-genomic signalling
JO  - Steroids
A1  - Davis, DeAsia
A1  - Dovey, Janine
A1  - Sagoshi, Shoko
A1  - Thaweepanyaporn, Kongkidakorn
A1  - Ogawa, Sonoko
A1  - Vasudevan, Nandini
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Sex and aggression are well studied examples of social behaviours that are common to most animals and are mediated by an evolutionary conserved group of interconnected nuclei in the brain called the social behaviour network. Though glucocorticoids and in particular estrogen regulate these social behaviours, their effects in the brain are generally thought to be mediated by genomic signalling, a slow transcriptional regulation mediated by nuclear hormone receptors. In the last decade or so, there has been renewed interest in understanding the physiological significance of rapid, non-genomic signalling mediated by steroids. Though the identity of the membrane hormone receptors that mediate this signalling is not clearly understood and appears to be different in different cell types, such signalling contributes to physiologically relevant behaviours such as sex and aggression. In this short review, we summarise the evidence for this phenomenon in the rodent, by focusing on estrogen and to some extent, glucocorticoid signalling. The use of these signals, in relation to genomic signalling is manifold and ranges from potentiation of transcription to the possible transduction of environmental signals.<p />  <p>Language: en</p>
LA  - en
SN  - 0039-128X
UR  - http://dx.doi.org/10.1016/j.steroids.2023.109324
ID  - ref1
ER  -