TY  - JOUR
PY  - 2023//
TI  - Prelimbic area to lateral hypothalamus circuit drives social aggression
JO  - iScience
A1  - Bai, Fuhai
A1  - Huang, Lu
A1  - Deng, Jiao
A1  - Long, Zonghong
A1  - Hao, Xianglin
A1  - Chen, Penghui
A1  - Wu, Guangyan
A1  - Wen, Huizhong
A1  - Deng, Qiangting
A1  - Bao, Xiaohang
A1  - Huang, Jing
A1  - Yang, Ming
A1  - Li, Defeng
A1  - Ren, Yukun
A1  - Zhang, Min
A1  - Xiong, Ying
A1  - Li, Hong
SP  - e107718
EP  - e107718
VL  - 26
IS  - 10
N2  - Controlling aggression is a vital skill in social species such as rodents and humans and has been associated with the medial prefrontal cortex (mPFC). In this study, we showed that during aggressive behavior, the activity of GABAergic neurons in the prelimbic area (PL) of the mPFC was significantly suppressed. Specific activation of GABAergic PL neurons significantly curbed male-to-male aggression and inhibited conditioned place preference (CPP) for aggression-paired contexts, whereas specific inhibition of GABAergic PL neurons brought about the opposite effect. Moreover, GABAergic projections from PL neurons to the lateral hypothalamus (LH) orexinergic neurons mediated aggressive behavior. Finally, directly modulated LH-orexinergic neurons influence aggressive behavior. These results suggest that GABAergic PL-orexinergic LH projection is an important control circuit for intermale aggressive behavior, both of which could be targets for curbing aggression.<p />  <p>Language: en</p>
LA  - en
SN  - 2589-0042
UR  - http://dx.doi.org/10.1016/j.isci.2023.107718
ID  - ref1
ER  -