TY  - JOUR
PY  - 2023//
TI  - Maternal childhood maltreatment: associations to offspring brain volume and white matter connectivity
JO  - Journal of developmental origins of health and disease
A1  - Lugo-Candelas, Claudia
A1  - Chang, Le
A1  - Dworkin, Jordan D.
A1  - Aw, Natalie
A1  - Fields, Andrea
A1  - Reed, Hannah
A1  - Spann, Marisa
A1  - Gilchrist, Michelle A.
A1  - Hinds, Walter
A1  - Marsh, Rachel
A1  - Fifer, William P.
A1  - Weissman, Myrna
A1  - Foerster, Bernd Uwe
A1  - Manin, Marina Giorgi
A1  - Silva, Ivaldo
A1  - Peterson, Bradley
A1  - Coelho Milani, Ana Carolina
A1  - Gingrich, Jay
A1  - Monk, Catherine
A1  - Duarte, Cristiane S.
A1  - Jackowski, Andrea
A1  - Posner, Jonathan
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - The deleterious effects of adversity are likely intergenerational, such that one generation's adverse experiences can affect the next. Epidemiological studies link maternal adversity to offspring depression and anxiety, possibly via transmission mechanisms that influence offspring fronto-limbic connectivity. However, studies have not thoroughly disassociated postnatal exposure effects nor considered the role of offspring sex. We utilized infant neuroimaging to test the hypothesis that maternal childhood maltreatment (CM) would be associated with increased fronto-limbic connectivity in infancy and tested brain-behavior associations in childhood. Ninety-two dyads participated (32 mothers with CM, 60 without; 52 infant females, 40 infant males). Women reported on their experiences of CM and non-sedated sleeping infants underwent MRIs at 2.44 ± 2.74 weeks. Brain volumes were estimated via structural MRI and white matter structural connectivity (fiber counts) via diffusion MRI with probabilistic tractography. A subset of parents (n = 36) reported on children's behaviors at age 5.17 ± 1.73 years. Males in the maltreatment group demonstrated greater intra-hemispheric fronto-limbic connectivity (b = 0.96, p= 0.008, [95%CI 0.25, 1.66]), no differences emerged for females. Fronto-limbic connectivity was related to somatic complaints in childhood only for males (r = 0.673, p = 0.006). Our findings suggest that CM could have intergenerational associations to offspring brain development, yet mechanistic studies are needed.<p />  <p>Language: en</p>
LA  - en
SN  - 2040-1744
UR  - http://dx.doi.org/10.1017/S2040174423000247
ID  - ref1
ER  -