TY  - JOUR
PY  - 2023//
TI  - Associations of depressive symptoms with subjective cognitive decline in elderly people-a cross-sectional analysis from the AgeWell.de-Study
JO  - Journal of clinical medicine
A1  - Zöllinger, Isabel
A1  - Bauer, Alexander
A1  - Blotenberg, Iris
A1  - Brettschneider, Christian
A1  - Buchholz, Maresa
A1  - Czock, David
A1  - Döhring, Juliane
A1  - Escales, Catharina
A1  - Fankhaenel, Thomas
A1  - Frese, Thomas
A1  - Hoffmann, Wolfgang
A1  - Kaduszkiewicz, Hanna
A1  - König, Hans-Helmut
A1  - Luppa, Melanie
A1  - Oey, Anke
A1  - Pabst, Alexander
A1  - Sanftenberg, Linda
A1  - Thyrian, Jochen René
A1  - Weiss, Julian
A1  - Wendel, Flora
A1  - Wiese, Birgitt
A1  - Riedel-Heller, Steffi G.
A1  - Gensichen, Jochen
SP  - 
EP  - 
VL  - 12
IS  - 16
N2  - To develop effective dementia prevention strategies, it is necessary to understand risk factors, associated factors and early signs of dementia. Subjective cognitive decline (SCD) is the earliest form of dementia. The aim of this study is to assess depression as a factor that is significantly associated with SCD. The data of 1030 general practitioner patients from the AgeWell.de-study (60-77 years; CAIDE dementia risk score ≥ 9) were analysed. A descriptive analysis was conducted using validated instruments like the Geriatric depression scale (GDS), Lubben social network scale (LSNS-6) and education classes according to CASMIN (Comparative Analysis of Social Mobility in Industrial Nations). A multivariate regression model with the dependent variable SCD was calculated. Of the 1030 participants, 5.9% had depressive symptoms and 31.3% SCD. The group with depressive symptoms showed significantly higher body-mass-index (p = 0.005), lower education class (p = 0.022), lower LSNS-6 score (p < 0.001), higher sports activity (p < 0.001), and more sleeping problems (p = 0.026). In the regression model a higher GDS-score [Odds ratio (OR): 1.219 (p < 0.001)], more sleeping problems [OR: 1.550 (p = 0.017)] and higher education class [middle/high: OR: 1.474/1.875 (p = 0.037/0.004)] were significantly associated with SCD. This study identified depressive symptoms, sleeping problems, and higher education classes as factors associated with SCD, which can represent an early form of dementia.<p />  <p>Language: en</p>
LA  - en
SN  - 2077-0383
UR  - http://dx.doi.org/10.3390/jcm12165205
ID  - ref1
ER  -