TY - JOUR
PY - 2023//
TI - Examination of proinflammatory activity as a moderator of the relation between momentary interpersonal stress and suicidal ideation
JO - Suicide and life-threatening behavior
A1 - Defayette, Annamarie B.
A1 - Esposito-Smythers, Christianne
A1 - Cero, Ian
A1 - Kleiman, Evan M.
A1 - López, Roberto Jr
A1 - Harris, Katherine M.
A1 - Whitmyre, Emma D.
SP - ePub
EP - ePub
VL - ePub
IS - ePub
N2 - INTRODUCTION: Peer-related interpersonal stress can increase risk for suicidal thoughts among adolescents and young adults. However, not all individuals who undergo peer-related interpersonal stressors experience suicidal thoughts. Heightened proinflammatory activity is one factor that may amplify the relation between interpersonal stress and suicidal thinking.
METHODS: This pilot study examined the relation between interpersonal stress and suicidal ideation in real time, as well as whether proinflammatory cytokine (IL-6 and TNF-α) activity across a laboratory social stressor moderated this association in a sample of 42 emerging adults with recent suicidal ideation. Participants completed 28 days of 6×/daily ecological momentary assessment that assessed for suicidal ideation (presence vs. absence, ideation intensity), occurrence of negative peer events, and feelings of exclusion.
RESULTS: There was a trend for within-person increases in feelings of exclusion to be associated with increases in concurrent suicidal ideation intensity. Additionally, within-person increases in negative peer events were associated with increased odds of subsequent suicidal ideation among individuals with very low IL-6 activity. However, this finding is considered preliminary.
CONCLUSION: Interventions targeting perceptions of exclusion and increasing social support may be of benefit. However, findings require replication in larger samples, and thus must be interpreted with caution. Language: en
LA - en
SN - 0363-0234
UR - http://dx.doi.org/10.1111/sltb.12993
ID - ref1
ER -