TY  - JOUR
PY  - 2023//
TI  - Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries
JO  - Lancet psychiatry
A1  - McGrath, John J.
A1  - Al-Hamzawi, Ali
A1  - Alonso, Jordi
A1  - Altwaijri, Yasmin
A1  - Andrade, Laura H.
A1  - Bromet, Evelyn J.
A1  - Bruffaerts, Ronny
A1  - de Almeida, José Miguel Caldas
A1  - Chardoul, Stephanie
A1  - Chiu, Wai Tat
A1  - Degenhardt, Louisa
A1  - Demler, Olga V.
A1  - Ferry, Finola
A1  - Gureje, Oye
A1  - Haro, Josep Maria
A1  - Karam, Elie G.
A1  - Karam, Georges
A1  - Khaled, Salma M.
A1  - Kovess-Masféty, Viviane
A1  - Magno, Marta
A1  - Medina-Mora, Maria Elena
A1  - Moskalewicz, Jacek
A1  - Navarro-Mateu, Fernando
A1  - Nishi, Daisuke
A1  - Plana-Ripoll, Oleguer
A1  - Posada-Villa, Jose
A1  - Rapsey, Charlene
A1  - Sampson, Nancy A.
A1  - Stagnaro, Juan Carlos
A1  - Stein, Dan J.
A1  - ten Have, Margreet
A1  - Torres, Yolanda
A1  - Vladescu, Cristian
A1  - Woodruff, Peter W.
A1  - Zarkov, Zahari
A1  - Kessler, Ronald C.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Information on the frequency and timing of mental disorder onsets across the lifespan is of fundamental importance for public health planning. Broad, cross-national estimates of this information from coordinated general population surveys were last updated in 2007. We aimed to provide updated and improved estimates of age-of-onset distributions, lifetime prevalence, and morbid risk. <br><br>METHODS: In this cross-national analysis, we analysed data from respondents aged 18 years or older to the World Mental Health surveys, a coordinated series of cross-sectional, face-to-face community epidemiological surveys administered between 2001 and 2022. In the surveys, the WHO Composite International Diagnostic Interview, a fully structured psychiatric diagnostic interview, was used to assess age of onset, lifetime prevalence, and morbid risk of 13 DSM-IV mental disorders until age 75 years across surveys by sex. We did not assess ethnicity. The surveys were geographically clustered and weighted to adjust for selection probability, and standard errors of incidence rates and cumulative incidence curves were calculated using the jackknife repeated replications simulation method, taking weighting and geographical clustering of data into account. <br><br>FINDINGS: We included 156 331 respondents from 32 surveys in 29 countries, including 12 low-income and middle-income countries and 17 high-income countries, and including 85 308 (54·5%) female respondents and 71 023 (45·4%) male respondents. The lifetime prevalence of any mental disorder was 28·6% (95% CI 27·9-29·2) for male respondents and 29·8% (29·2-30·3) for female respondents. Morbid risk of any mental disorder by age 75 years was 46·4% (44·9-47·8) for male respondents and 53·1% (51·9-54·3) for female respondents. Conditional probabilities of first onset peaked at approximately age 15 years, with a median age of onset of 19 years (IQR 14-32) for male respondents and 20 years (12-36) for female respondents. The two most prevalent disorders were alcohol use disorder and major depressive disorder for male respondents and major depressive disorder and specific phobia for female respondents. <br><br>INTERPRETATION: By age 75 years, approximately half the population can expect to develop one or more of the 13 mental disorders considered in this Article. These disorders typically first emerge in childhood, adolescence, or young adulthood. Services should have the capacity to detect and treat common mental disorders promptly and to optimise care that suits people at these crucial parts of the life course. FUNDING: None.<p />  <p>Language: en</p>
LA  - en
SN  - 2215-0374
UR  - http://dx.doi.org/10.1016/S2215-0366(23)00193-1
ID  - ref1
ER  -