TY  - JOUR
PY  - 2023//
TI  - Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: a hospital based cross-sectional study
JO  - Indian journal of psychiatry
A1  - Singh, Aru Shikha
A1  - Borgohain, Lakshimi
A1  - Singh, Bhupindar
SP  - 667
EP  - 670
VL  - 65
IS  - 6
N2  - BACKGROUND: The correlation between plasma C-reactive protein (CRP) and aggression in schizophrenia has recently become an area of interest. As an acute phase reactant, neuro-immuno-modulatory and neurohumoral functions of CRP might have a role in understanding causation of aggression in disease and this may have implications in therapeutic intervention. AIMS: To assess aggression and plasma CRP in patients with schizophrenia and to compare aggression in patients with normal and elevated CRP. <br><br>METHODS AND MATERIAL: A hospital-based cross-sectional study was carried out over a period of one year (2019-2020). Patients of schizophrenia as per International Classification of Diseases 10 were selected. Modified Overt Aggression Scale was applied, and plasma CRP levels were estimated in the selected patients. STATISTICAL ANALYSIS: Mean aggression scores were compared in patients with normal and elevated CRP. And aggression scores were correlated with plasma CRP levels. <br><br>RESULTS: Mean aggression score (22.93 ± 2.80) was significantly (P <.001) higher in patients with elevated CRP. There is a positive correlation (r = 0.855, P <.001) between aggression and plasma CRP. <br><br>CONCLUSION: Patients with elevated CRP were more aggressive compared to the patients with normal CRP.<p />  <p>Language: en</p>
LA  - en
SN  - 0019-5545
UR  - http://dx.doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_427_22
ID  - ref1
ER  -