TY  - JOUR
PY  - 2023//
TI  - Standing blood pressure and risk of falls, syncope, coronary heart disease, and mortality
JO  - American journal of hypertension
A1  - Kondo, Jordan K.
A1  - Earle, William
A1  - Turkson-Ocran, Ruth-Alma N.
A1  - Ngo, Long H.
A1  - Cluett, Jennifer L.
A1  - Lipsitz, Lewis A.
A1  - Daya, Natalie R.
A1  - Selvin, Elizabeth
A1  - Lutsey, Pamela L.
A1  - Coresh, Josef
A1  - Windham, Beverly Gwen
A1  - Kendrick, Karla N.
A1  - Juraschek, Stephen P.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: ACC/AHA guidelines caution against the use of antihypertensive therapy in the setting of low standing systolic BP (SBP) <110 mmHg due to unclear benefits. <br><br>METHODS: The Atherosclerosis Risk in Communities (ARIC) Study measured supine and standing SBP in adults aged 45-64 years between 1987-1989. We used Cox regression to evaluate the associations of low standing SBP (<110 mmHg) with risk of falls, syncope, coronary heart disease (CHD), and mortality through December 31, 2019. Falls and syncope were ascertained by hospitalization and outpatient claims; CHD events were adjudicated. Associations were examined overall and in strata of hypertension stage, 10-year atherosclerotic cardiovascular disease (ASCVD) risk, age, and sex. <br><br>RESULTS: Among 12,467 adults followed a median of 24 years (mean age at enrollment 54.1±5.8 years, 55% women, 26% Black adults), 3000 (24%) had a standing SBP <110 mmHg. A standing SBP <110 mmHg compared to standing SBP ≥110 mmHg was not significantly associated with falls or syncope, and was associated with a lower risk of CHD events and mortality with HRs of 1.02 (95% CI 0.94, 1.11), 1.02 (0.93, 1.11), 0.88 (0.80, 0.97), and 0.91 (0.86, 0.97), respectively. There were no clinically meaningful differences when stratified by hypertension stage, 10-year ASCVD risk, age, and sex. <br><br>CONCLUSIONS: In this community-based population, low standing SBP was common and not significantly associated with falls or syncope, but was associated with a lower risk of CHD and mortality. These findings do not support screening for low standing BP as a risk factor for adverse events.<p />  <p>Language: en</p>
LA  - en
SN  - 0895-7061
UR  - http://dx.doi.org/10.1093/ajh/hpad064
ID  - ref1
ER  -