TY  - JOUR
PY  - 2023//
TI  - A multidimensional approach to assessing factors impacting health-related quality of life after pediatric traumatic brain injury
JO  - Journal of clinical medicine
A1  - von Steinbuechel, Nicole
A1  - Krenz, Ugne
A1  - Bockhop, Fabian
A1  - Koerte, Inga K.
A1  - Timmermann, Dagmar
A1  - Cunitz, Katrin
A1  - Zeldovich, Marina
A1  - Andelic, Nada
A1  - Rojczyk, Philine
A1  - Bonfert, Michaela Veronika
A1  - Berweck, Steffen
A1  - Kieslich, Matthias
A1  - Brockmann, Knut
A1  - Roediger, Maike
A1  - Lendt, Michael
A1  - Buchheim, Anna
A1  - Muehlan, Holger
A1  - Holloway, Ivana
A1  - Olabarrieta-Landa, Laiene
SP  - 
EP  - 
VL  - 12
IS  - 12
N2  - In the field of pediatric traumatic brain injury (TBI), relationships between pre-injury and injury-related characteristics and post-TBI outcomes (functional recovery, post-concussion depression, anxiety) and their impact on disease-specific health-related quality of life (HRQoL) are under-investigated. Here, a multidimensional conceptual model was tested using a structural equation model (SEM). The final SEM evaluates the associations between these four latent variables. We retrospectively investigated 152 children (8-12 years) and 148 adolescents (13-17 years) after TBI at the recruiting clinics or online. The final SEM displayed a fair goodness-of-fit (SRMR = 0.09, RMSEA = 0.08 with 90% CI [0.068, 0.085], GFI = 0.87, CFI = 0.83), explaining 39% of the variance across the four latent variables and 45% of the variance in HRQoL in particular. The relationships between pre-injury and post-injury outcomes and between post-injury outcomes and TBI-specific HRQoL were moderately strong. Especially, pre-injury characteristics (children's age, sensory, cognitive, or physical impairments, neurological and chronic diseases, and parental education) may aggravate post-injury outcomes, which in turn may influence TBI-specific HRQoL negatively. Thus, the SEM comprises potential risk factors for developing negative post-injury outcomes, impacting TBI-specific HRQoL. Our findings may assist healthcare providers and parents in the management, therapy, rehabilitation, and care of pediatric individuals after TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 2077-0383
UR  - http://dx.doi.org/10.3390/jcm12123895
ID  - ref1
ER  -